Presley Gerber openly addressed his mental health struggles in a 2023 episode of the "Studio 22" podcast. He expressed his desire to help others, stating, "I think that whether I help one person or a hundred people get out of that place that I was in at one point in my life, that's all I need to do." Gerber, the son of supermodel Cindy Crawford and businessman Rande Gerber, had struggled with depression and other mental health issues. He died at a rehabilitation facility on September 20, as confirmed by records from the Los Angeles County Medical Examiner.

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During the podcast, Gerber reflected on the ongoing nature of his recovery, describing it as "a 24/7 job" with many complexities. He aimed to use his experiences to assist others facing similar challenges, stating, "That's really what I want to do is help people—whether you're depressed, you're struggling with something that is having a negative effect on your body." He emphasized a non-judgmental approach, sharing hopes that his past mistakes might guide others away from similar paths.

In addition to his podcast appearances, Gerber highlighted his mental health journey through a social media series titled "Mental Health Monday." In a since-deleted Instagram video from December 2025, he discussed the fear of navigating various medical opinions about his treatment. At that time, he was using multiple medications, including opiates, antidepressants, benzodiazepines, and undergoing ketamine infusions.

Gerber’s sister, Kaia Gerber, spoke about their family dynamics and her brother's struggles in an interview with Vogue published in August. She noted the impact of addiction on the family, stating, "When something like that happens in a family, it kind of levels everyone." Kaia also shared her feelings about always wanting to be seen as the "easy one" and not wanting to ask for help, as she described the challenges posed by having a sibling struggling with addiction.

Kaia reflected on Presley’s decision to be transparent about his issues, contrasting it with their parents' more private approach to family matters. She commented, "There's only so much you can hide from the world. And trying to put a lid on something just makes the person feel like you're ashamed of them."